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The tragic loss of a renowned celebrity or athlete to a drug or alcohol-related death is an event that often leaves many unanswered questions. Famous and much-loved celebrities such as Michael Jackson, Whitney Houston, and Heath Ledger have been the victims of such unfortunate circumstances.

While many deaths may be due to misuse of illegal substances, these drugs are not always illicit – and an overdose may not always be intentional.

Drug Interactions Can Be Deadly

Death due to drugs can also be the result of mixing prescribed medications with other drugs (legal or illegal), alcohol, over-the-counter medications or even herbal supplements. 

Drug-drug interactions may also play a role in drug-related deaths. For example, the consumption of multiple central nervous system depressants, such as opioid pain killers, sedatives, hypnotics, or alcohol may lead to an unintentional overdose due to severely depressed breathing.

Mixing illicit, prescription or over-the-counter medications can be dangerous, and patients should always rule out drug interactions with their healthcare provider.

The use of prescription medications with illegal drugs or alcohol can produce an unpredictable and fatal response, and many deaths due to such circumstances may have been preventable.

The following table outlines the death of notable celebrities and athletes who have had drugs or alcohol implicated in their deaths.

2018 and back – Let’s stop this BS

NameNotable FameCause of DeathDrug CategoryWhenAge
Mac MillerAmerican rapper, singer, and record producerAccidental overdose of fentanyl, cocaine and alcoholPrescription drugs and alcohol201826
Verne TroyerAmerican actor (Mini-Me in the Austin Powers film series)Suicide by alcohol poisoningAlcohol201849
Dolores O’RiordanIrish musician, singer and songwriter (The Cranberries)Accidental drowning due to alcohol intoxicationAlcohol201846
Art BellAmerican broadcaster and authorAccidental overdose from prescription drugs including oxycodone, hydrocodone, diazepam, and carisoprodolPrescription drugs201872
Lil PeepAmerican rapper and singerOverdose of fentanyl and XanaxPrescription drugs201721
Tom PettyAmerican singer and songwriterAccidental overdose of prescription drugs including fentanyl and oxycodonePrescription drugs201766
PrinceAmerican singer and songwriterAccidental fentanyl overdosePrescription drug201657
ChynaAmerican professional wrestlerAccidental overdose of alcohol and prescription drugs including diazepam, oxycodone, oxymorphone, and temazepamPrescription drugs and alcohol201646
José FernándezCuban-American professional baseball pitcher (Miami Marlins)Boating accident while under the influence of cocaine and alcoholIllegal drug and alcohol201624
Scott WeilandAmerican musician, singer and songwriterAccidental overdose of cocaine, alcohol, and methylenedioxyamphetamine (MDA)Illegal drugs and alcohol201548
Philip Seymour HoffmanActorAcute mixed drug intoxication, including heroin, cocaine, benzodiazepines and amphetamineMixed illegal and prescription drugs201446
Joan RiversActressTherapeutic complication with propofol sedationPrescription drugs201481
Peaches GeldofEnglish columnist, television personality, and modelHeroin overdoseIllegal drug201425
Cory MonteithActor (Glee) and singerToxic mix of heroin and alcoholIllegal drug and alcohol201331
Lisa Robin KellyActress (That ’70s Show)Multiple drug intoxicationIllegal drug201343
Chris KellyRapper (Kris Kross)Fatal overdose, cocaine and heroinIllegal drug201334
Jeff HannemanMusician (Slayer)Cirrhosis due to alcoholismAlcohol201349
Whitney HoustonAmerican singer, actressDrowning; complications of cocaine and heart disease; Flexeril, marijuana, Xanax and Benadryl also found in body but did not contribute to deathIllegal drug201248
Michael Carl BazeHorse jockeyOverdose; cocaine, oxymorphone (accidental)Mixed illegal and prescription drugs201124
Derek BoogaardCanadian professional ice hockey player; left wing (New York Rangers)Alcohol and oxycodone overdose (accidental)Mixed alcohol and prescription drugs201128
Amy WinehouseEnglish singer and songwriterFatal alcohol poisoning; alcoholismAlcohol201127
Erica BlasbergAmerican golfer (LPGA)Asphyxia; multiple drug overdose: butalbital, temazepam, alprazolam, codeine, hydrocodone, and tramadol (suicide)Prescription drugs201025
Andy IronsSurferCardiac arrest complicated by mixed drug ingestion (cocaine, methamphetamine, alprazolam, methadone)Mixed illegal and prescription drugs201032
Edward Fatu “Umaga”Samoan-American professional wrestlerHydrocodone, carisoprodol, diazepam (accidental)Prescription drug overdose200936
Michael JacksonAmerican Pop Singer and iconCardiac arrest, acute propofol intoxication; midazolam, lidocaine, diazepam, lorazepam also noted in autopsy reportPrescription drugs200950
Billy MaysSpokespersonHeart disease possibly complicated by cocaine useIllegal drug200951
Christopher BowmanAmerican figure skaterDrug overdose: cocaine, diazepam, cannabis, alcohol (accidental)Mixed alcohol, illegal and prescription drugs200840
Heath LedgerAustralian actorCombined drug toxicity due to oxycodone, hydrocodone, alprazolam, diazepam, temazepam, doxylamine (accidental)Prescription drug overdose200828
Scott Charles (“Bam Bam”) BigelowAmerican professional wrestler; World Wrestling Federation (WWF) and World Championship Wrestling (WCW)Multiple drug overdose: cocaine, temazepam (accidental), possibly worsened by heart diseaseMixed illegal and prescription drugs200745
Chris MainwaringAustralian Football PlayerCocaine overdose (accidental)Illegal drug200741
Anna Nicole SmithAmerican model, Playboy playmate, actressCombined drug toxicity due to chloral hydrate and benzodiazepines (accidental)Prescription drugs200740
Ike TurnerMusician, bandleader, songwriter, producerCardiovascular, lung disease complicated by cocaine overdose (accidental)Illegal drug200776
George BestProfessional soccer playerComplications due to alcohol abuse, alcoholismAlcohol200559
Eddie GuerreroProfessional wrestlerCardiomyopathy, heart disease, possibly due to anabolic steroid useAnabolic steroids (speculated)200538
Steven Scott BechlerMajor League baseball pitcher; Baltimore OriolesHeat stroke exacerbated by ephedraAlternative/herbal drug200323
Anthony DuranteProfessional wrestlerOxycodone or fentanyl overdose (accidental)Prescription drug overdose200336
Howie EpsteinAmerican bass guitarist (Tom Petty and the Heartbreakers)Possible heroin overdose; also reportedly using prescription antibioticsIllegal drug overdose200347
Elisa BridgesAmerican model, actressDrug overdose: heroin, methamphetamine, alprazolam, meperidineMixed illegal and prescription drugs200228
Douglas Glenn Colvin, aka Dee Dee RamoneAmerican songwriter and musician (The Ramones)Heroin overdose (accidental)Illegal drug200250
John EntwistleEnglish bass guitarist (The Who)Heart attack induced by cocaineIllegal drug200258
Darrell PorterAmerican professional baseball playerCocaine overdose (accident)Illegal drug200250
Christopher Wiley AntleyHorse jockey; 2-time Kentucky Derby winnerOverdose; (clobenzorex, paroxetine, methamphetamine, carbamazepine) and trauma (accidental)Prescription drugs200034
Chris FarleyComedian, actor; Saturday Night Live sketch comedy TV showOverdose; combination of morphine and cocaine; complicated by heart disease; fluoxetine also in system (accidental)Illegal drugs199733
Peter JacksonAustralian rugby playerHeroin overdose (suicide)Illegal drug199733
Margeaux HemingwayAmerican actressPhenobarbital overdose; suicidePrescription drug overdose199642
Phyllis HymanAmerican singer, songwriter and actressFatal overdose of pentobarbital and secobarbital (suicide)Prescription drugs199545
Kurt CobainAmerican singer-songwriter and musician (Nirvana)Gunshot wound to head; heroin and diazepam found in body (suicide)Mixed illegal and prescription drugs199427
River PhoenixAmerican actorHeroin and cocaine overdoseIllegal drugs199323
David WaymerAmerican football player, NFLHeart attack, cocaine relatedIllegal drug199334
Paul HaywardProfessional Rugby League Player; Newton Jets (Australia)Heroin overdose; contracted HIV in prisonIllegal drug overdose199238
John KordicProfessional hockey playerLung failure complicated by unspecified drug overdose (possible anabolic steroid abuse)unknown199227
Abbie HoffmanAmerican Political activistPhenobarbital overdose (suicide)Prescription drug overdose198952
Chet BakerJazz musician and singer, trumpet player, guitaristAccidental fall from hotel window; cocaine, heroinIllegal drugs198859
David CroudipAmerican football defensive cornerback for the Atlanta FalconsCocaine overdose (accidental)Illegal drug198830
Len BiasBoston Celtics second overall NBA draft pick (1986)Cardiac arrhythmia induced by a cocaine overdose (accidental)Illegal drug198623
Don RogersFootball safety in the National Football League (US), Cleveland BrownsFatal cocaine overdose (accidental)Illegal drug198623
Richard BurtonWelsh-born actorCerebral hemorrhage; possible complications due to alcohol, alcoholismAlcohol198458
Truman CapoteAmerican writerLiver disease complicated by phlebitis, alcohol and multiple drug intoxicationAlcohol198459
David KennedyFourth son of Robert F. Kennedy; no professionOverdose of cocaine, meperidine, thioridazine (controversial, some say he was murdered)Mixed illegal and prescription drugs198428
John BelushiAmerican actor; comedian; musician; Saturday Night Live comedy TV showSpeedball overdose; a combination of heroin and cocaine (accidental)Illegal drugs198233
Jon BonhamEnglish musician (drummer) and songwriter (Led Zeppelin)Asphyxiation due to massive alcohol consumptionAlcohol198032
John Simon Ritchie, aka Sid ViciousMusician (Sex Pistols)Heroin overdose (suicide)Illegal drug197921
Keith MoonDrummer (The Who)Clomethiazole overdosePrescription drug197832
Elvis PresleyAmerican musician, singer, actor, cultural iconHeart arrhythmia, possibly aggravated by multiple prescriptions (methaqualone, codeine, barbiturates, cocaine), speculatedMixed illegal and prescription drugs, speculated197742
Freddie PrinzeActorSelf-inflicted gunshot; possibly under influence of methaqualone, cocaine (suicide)Mixed illegal and prescription drugs, speculated197722
Howard HughesAmerican business tycoon, movie producer and director, aviator, engineer, investorKidney failure; possible complications due to chronic use of aspirin (high doses) and dehydrationNonprescription drug (not confirmed)197670
Bruce LeeMartial artist, actor, film director, pop culture iconCerebral edema due to meprobramate, aspirinPrescription drug overdose197332
Jim MorrisonMusician, singer, songwriter (The Doors)Heart failure; possible heroin or cocaine overdose (disputed)Illegal drug197127
Jimi HendrixAmerican musician and singer-songwriterRespiratory arrest, asphyxia due to alcohol and barbiturate overdose; vomit inhalationMixed alcohol and prescription drugs197027
Janis JoplinAmerican musicianHeroin overdoseIllegal drug197027
Judy GarlandAmerican actress and singerBarbiturate (Seconal) overdose; controversial if suicide or accidentPrescription drug overdose196947
Brian JonesMusician (The Rolling Stones)Drowning due to alcohol and drug intoxicationunknown196927
Jack KerouacAuthorCirrhosis of liver, internal bleeding due to alcohol useAlcohol196947
Brian EpsteinEnglish businessman; manager (The Beatles)Sedative overdose (accidental)Prescription drug overdose196732
Lenny BruceAmerican comedianDrug overdose: morphine (accidental)Illegal drugs196640
Eugene “Big Daddy” LipscombFootball defensive lineman in the National Football League (US), Pittsburgh Steelers; professional wrestlerHeroin overdose (accidental)Illegal drug196331
Marilyn MonroeAmerican actress, model, singer, sex symbolBarbiturate overdose (suicide)Prescription drug196236
Billy HolidayAmerican jazz singer and songwriterCirrhosis of the liver due to alcohol; alcoholismAlcohol195944
Joseph McCarthyU.S. SenatorHepatitis exacerbated by alcohol, alcoholismAlcohol195748
Tommy DorseyAmerican jazz musicianChoked himself while sleeping; unable to awaken due to sedative usePrescription drug overdose195651
Hank Williams, Sr.Country music singer-songwriterHeart failure, possibly alcohol, drug-related (accidental)Mixed alcohol and Illegal drugs (speculated)195329
Sigmund FreudNeurologistPhysician-assisted suicide; morphinePrescription drug overdose193983

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